John N. Constantino, M.D
Professor of Psychiatry and Pediatrics at the Washington University School of Medicine in St. Louis, Missouri
John N. Constantino, M.D., is the Blanche F. Ittleson Professor of Psychiatry and Pediatrics at the Washington University School of Medicine in St. Louis, Missouri, where he is Director of the William Greenleaf Eliot Division of Child and Adolescent Psychiatry, principal investigator of an NICHD Intellectual and Developmental Disabilities Research Center, and Psychiatrist-In-Chief of St. Louis Children’s Hospital. Dr. Constantino’s work has focused on understanding genetic and environmental influences on social development in childhood. In collaborations with Drs. Richard D. Todd, James J. Hudziak (Univ. Vermont), Daniel H. Geschwind (UCLA), Thomas W. Frazier (Cleveland Clinic), Christian P. Gruber (Western Psychological Services), Paul Law (Johns Hopkins University) and others, Dr. Constantino’s team developed and advanced methods for measuring autistic social impairment as a quantitative trait, allowing patterns of transmission of autistic syndromes and sub clinical autistic traits to be traced in families and populations. These studies have helped elucidate the factoral and genetic structure of autism, and the nature of its pronounced sex ratio. Most recently these measurements have proven capable of specifying elevations in offspring risk for autism and variation in social-adaptive functioning across diverse child psychiatric syndromes. These findings have significant implications for gene discovery, the identification of new targets for biological and developmental therapy, genetic counseling, and preventing impairment in adaptive functioning that is incurred by autism and other disorders of social development in childhood.
Watch Replay - Recorded on July 21, 2016